Tapasyas high shear mixer granulator is designed to meet special needs of tablet formulation technology. Production plants glatt integrated process solutions. A high shear mixer uses a rotating impeller or high speed rotor or both to create flow and shear. Implementation of granulation bowl manually, pneumatically, or by vacuum or gravity. The mic developer, high shear granulator has the ability to control the four critical parameters of nucleation mentioned above. Vertical granulator with patented zform rotor wings for particularly fast wet granulation with high granulate density and optimal particle stability. Ointement planetory mixer for ointment cream lotion paste etc. Powder flow in vertical high shear mixer granulators uq espace. The water spray rate of the scaleup batches was increased as a.
Weight l b h in kg taphsmgr2t25 25 20 600 0 7 800 taphsmgr2t75 75 60 2150 2450 2400 1500. Model gross capacity in liters working capacity in liters overall dimensions in mm motor hp approx. Rapid mixer granulator working principle pharma manual. Glatt high shear granulation by high shear granulator. High shear mixer granulatorhigh speed mixer granulator. Pma high shear and pmaadvanced mixer and granulator is a multipurpose processor thats equally suitable for the high speed dispersion of dry powders, aqueous or solvent granulations, effervescent production and melt pelletization for pharma applications. This sop shall be applicable for rapid mixer granulator capacity150 liter in granulation area in the production department. Professional high shear granulator precision high speed. Pma high shear processor gea engineering for a better.
High shear granulators gea engineering for a better world. Highshear granulatorsmixers are used throughout the chemical process industries, wherever it is necessary to produce mixtures of ingredients that do not naturally mix immiscible. Used collette high shear granulator, model ultimagral 1200. They have the following advantages over other granulators 1. A highshear granulator consists of a cylindrical or conical mixing bowl, a threebladed impeller, a chopper, an auxiliary chopper, a motor to drive the blades and a discharge pot. Creating a quality product the dome shaped lid permits product to perform a complete roll over as it moves up the side of the vessel wall.
Ross kneader extruders combines the efficiency of a double arm sigma blade mixer with the convenience of an extrusion screw. The l5ma laboratory mixer is suitable for the widest range of applications mixing, emulsifying, homogenizing, disintegrating and dissolving. A wide range of impeller and chopper speeds, sensitive liquid flow rate control and droplet size along with impeller torque help to keep the control over the granulation process. For wet granulation, choppers and impellers are mainly responsible in rapid granulator. High speed mixer granulators are commonly used in agrochemical, detergent, and pharmaceutical industries due to their capability to manage difficult feed formulations, comprising of fine cohesive powders and high viscosity binder fluids.
Being the world leader in high shear mixer granulators, tapasyas quest for continuous improvement of the. The latest development in high shear lab mixing the new silverson l5ma is ideal for all laboratory work, research and development, qa analysis and small scale production in all industries. Wet granulation in laboratoryscale high shear mixers. High shear granulators glatt integrated process solutions. Buy and sell, new and used high shear granulators on labx. Browse labx classified ads and auctions today to find the best price on a wide selection of high shear granulators and more. In pharmaceutical industry rapid mixer granulator plays vital role to mix the ingredients and make granules before compression. By either circulating hot or cool liquid or steam through the jacket, the mixing bowl is jacketed for heating or cooling the contents of the bowl as the case may be. This equipment has functions of mixing, granulation and mill. To keep the froude number constant, the impeller speed was set at 597 rpm for the pma1, and 435 rpm for the pma65. To lay down the procedure for operation of rapid mixer granulator. Qualtech products industry high shear granulator is a production scale granulator offering high efficiency and reliable performance this high speed granulator is designed and engineered to mix powder particles and. Pdf design of experimental high shear granulator for the.
Our high shear batch and inline mixers, sanitary mixers and blenders, vacuum homogenizers and other industrial mixing equipment are used for liquidsolid liquidliquid and solidsolid mixing and blending applications in the adhesive, battery, chemical, cosmetic. Single pot granulation the granulation is done in a normalhigh shear processor and dried in sameequipment. The bowl geometry is optimized to permit working volumes from 3090% of full capacity. High shear mixer granulator tapasyas high shear mixer granulator is designed to meet special needs of tablet formulation technology. In fact, there are an enormous range of geometries and designs. Rapid mixer granulator rmg high shear mixer granulator 25 40 60 100 150 250 300 400 500 kgs. Chapter 1 high shear granulation request pdf researchgate. A highshear mixer uses a rotating impeller or highspeed rotor or both to create flow and shear. The pharmx highshear granulator has a mixing bowl with a bottomdriven mixing impeller and side mounted chopper. Rapid mixer granulator rmg machine, high shear mixers for. The ultimagral design allows for different ways of setting up a standalone machine in a gmpcompliant way.
The speed of the fluidpowder at the outside of the rotor will be higher than the speed of the fluidpowder at the center of the rotor. Smgh series mixer and granulator is one of the standard process equipments in the solid dosage production procedure in pharmaceutical industry, and is also widely used in chemical, foodstuff industries, etc. Methods contd single pot granulation high shear mixture granulation fluid bed granulation extrusion spheronization12720 satara college of pharmacy, satara. Standard operating procedure of rapid mixer granulator used in manufacturing of granules for tablets. Modular construction for individual configuration and adaption to your specific needs. As the name suggests this machines performs two operations mixing and granulating after mixing of dry powdersgranules, subsequent wet granulation occurs. It is the only granulator that not only meets all the stringent quality requirements of the fda cgmp, but also meets the specific needs of customers, with its, distinct torquebased granulation endpoint determination. It also shows the setup of a professional high shear granulator, aka high shear mixer and its key components. Remember, this an essential material processing machine in the food, pharmaceutical and cosmetic industries.
With a large, color touch screen operator interface, the kg5 is easy to use and generates meaningful product performance data. Fielder pma300 300 liters high shear granulator other views click image for larger view. The tip velocity, or speed of the fluid at the outside edge of the rotor, will be higher than the velocity at the center of the rotor, and it is this difference in velocity that creates shear. Mixing chambers in rapid mixer granulator is of 3 types conical shaped, domed shape, and circular shaped although the basic aim behind all the shapes is to eliminate the dead points and wall adhesion i. Dry powders are first loaded into the granulator by vacuum or gravity total containment is simple, call for details. Ross is the leading manufacturer of high shear rotorstator mixer homogenizers and highspeed dispersion equipment for the adhesives, chemical, cosmetic, food pharmaceutical and plastics industries. Effect of chopper presence, design and impeller speed. Rapid mixer granulator rmg machine, high shear mixers. Used 300 liter niro fielder high shear mixer, model pma 300, stainless steel construction, on stainless steel base with 10 hp chopper. Smgh 501200 high shear mixer granulator application. High shear mixer granulator, rapid mixer granulator. Definition of lodige on continuous high shear granulation.
Powder flow in vertical high shear mixer granulators. This is achieved by reducing processing time, homogeneous mixing, even distribution of binder, wetting, nucleation and granule size growth with sampling provision for in process analysis and. High shear mixing equipment ross industrial mixers. The kg5 is a cost effective, stateoftheart, bench top high shear granulatormixer. Mixer granulators or high shear granulators have a wide range of applications in the pharmaceutical, agrochem ical and detergent industries. Ross designs and manufactures industrial high shear mixers, dispersers, for the process industries. High shear granulating is a highly effective method of producing a uniform dense granule. The highshear wet granulation process was scaled up to 1. An experimental study has been carried out on the solids motion in a conical frustumshaped vertical high shear mixer granulator by using the positron. Vertical mixing improved with higher bladerake angle due to an increased thickness of the shear transmission layer however no significant improvements were. High shear granulators new and used pharmaceutical. The diosna granulators are extremely quick and efficient mixers of dry powders.
Scaleup of highshear mixer granulators request pdf. Validity of the proposed scaleup method was confirmed by an experiment of wetgranulation using a commercial high shear mixergranulator with different vessel sizes 2 to. Mixing of dry powders such as api and excipients, for. High shear mixer granulator r2t was introduced with the feature of direct drive technology. This animation illustrates the process of high shear granulation. Many applications of a highshear mixergranulator do not require integration with other equipment.
Mixer granulators or high shear granulators have a wide range of applications in the pharmaceutical, agrochemical, and detergent industries. Most of the high shear granulators consist of a mixing bowl, a three bladed impeller and a secondary mixer or chopper see fig. Impeller torque and motor power consumption for a small high shear mixer fielder pma 10. High shear mixer granulator r2t 11 high shear mixer granulator r2t tapasyas hsmg enjoys the trust and confidence of customers, the world over, for its unparalleled quality, unique features and reliable performance. Well, in this article, youre going to learn about some key aspects of a high shear mixer granulator.